When dealing with reagent line clogging in used nucleic acid synthesizers, you can refer to the following general steps (please follow the instrument manual or seek professional help for specific operations):

1. Safety first: Power off the instrument and disconnect relevant reagent supply lines to avoid accidental leakage or damage.
2. Locate the clog: Identify the specific clogged section of the reagent line through visual inspection or pressure testing.
3. Unclogging operations: Depending on the nature of the clog (e.g., dried reagent residues), use compatible solvents for flushing (ensure the solvent does not corrode the line material), or disassemble detachable parts for gentle cleaning (such as using ultrasonic cleaners for small components). Avoid using harsh mechanical methods that may damage the line.
4. Post-processing: After unclogging, reassemble the lines, perform leak tests, and run a functional verification to ensure normal operation.

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