When repairing the Agilent 6530 Q-TOF mass spectrometer due to ion source blockage causing reduced sensitivity, the following operational details should be noted:

1. Safety precautions: Power off the instrument and disconnect it from the power supply before starting any disassembly work to avoid electrical risks.
2. Standardized disassembly: Follow Agilent's official maintenance procedures to take apart ion source components (such as spray needle, capillary, ion funnel, etc.) using appropriate tools.
3. Proper cleaning: Use compatible solvents (e.g., methanol, acetonitrile, isopropanol) to clean contaminated parts; avoid harsh chemicals or abrasive materials that may damage the components.
4. Component inspection: Check each part for wear or damage (like bent spray needles, cracked insulators) during cleaning; replace worn-out parts promptly.
5. Precise reassembly: Reassemble the ion source components in the correct order and ensure accurate alignment (misalignment can still affect sensitivity after cleaning).
6. Post-repair verification: Perform leak tests and instrument calibration after reassembly to confirm the blockage is resolved and sensitivity is restored.
7. Documentation: Record all repair steps, cleaning agents used, and parts replaced for future reference.

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